Abstract |
The present study was conducted to investigate the therapeutic effects of nilvadipine, a Ca2+ entry blocker, on rat focal cerebral ischemia. Under halothane anesthesia, a 3-0 nylon thread was introduced into the neck internal carotid artery to occlude the left middle cerebral artery. Either nilvadipine (3.2 mg/kg) or vehicle was administered subcutaneously 1, 2, 3, 4, 5 and 6 h following the occlusion (groups 1-6, respectively). Twenty-four hours after the occlusion, the percentage infarct volumes in nilvadipine-treated animals in groups 1-3 (21 +/- 11%, 24 +/- 11%, and 26 +/- 7%, respectively) were smaller than those in the respective control groups (36 +/- 5%, 35 +/- 3%, and 35 +/- 3%; P < 0.05). Compared with controls, the infarct size of the periphery of the fronto-parietal cortex decreased in nilvadipine-treated animals. The results indicate that nilvadipine decreases the size of infarction when administered up to 3 h after an ischemic insult. Thus, nilvadipine can be considered a potential therapeutic agent for acute focal cerebral ischemia, and may be clinically useful in stroke patients.
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Authors | Y Li, S Kawamura, N Yasui, M Shirasawa, H Fukasawa |
Journal | Experimental brain research
(Exp Brain Res)
Vol. 99
Issue 1
Pg. 1-6
( 1994)
ISSN: 0014-4819 [Print] Germany |
PMID | 7925784
(Publication Type: Journal Article)
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Chemical References |
- Calcium Channel Blockers
- nilvadipine
- Nifedipine
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Topics |
- Animals
- Blood Pressure
(drug effects, physiology)
- Brain
(pathology)
- Calcium Channel Blockers
(therapeutic use)
- Cerebral Arteries
(physiology)
- Cerebral Infarction
(pathology)
- Ischemic Attack, Transient
(drug therapy, pathology)
- Nifedipine
(analogs & derivatives, therapeutic use)
- Optic Chiasm
(pathology)
- Rats
- Rats, Sprague-Dawley
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