Delayed treatment with 1,3-butanediol reduces loss of CA1 neurons in the hippocampus of rats following brief forebrain ischemia.

Abstract

This study examined the effect of 1,3-butanediol on the selective loss of CA1 pyramidal neurons following a short period of near-complete forebrain ischemia. Injection of 55 mmol 1,3-butanediol/kg body weight at 24 h of recirculation and again at 36 h following 10 min of forebrain ischemia markedly reduced damage to CA1 neurons examined at 72 h of recirculation compared with that in saline-treated rats. Comparable treatment with ethanol did not cause significant protection. Neuronal loss was also not reduced by 1,3-butanediol treatment when the ischemic period was extended to 15 min or by single treatments at 24 h or 36 h following 10 min of ischemia. However, a single treatment 5 min after reversal of 10 min of ischemia was effective in ameliorating cell loss. The difference in effectiveness of 1,3-butanediol following 10 min and 15 min of ischemia is consistent with a number of previous studies, indicating that the processes leading to loss of CA1 neurons are modified when the ischemic period is extended. Previous findings that 1,3-butanediol reduced damage in other ischemia-susceptible neuronal subpopulations but not in CA1 neurons most likely reflected the longer period of ischemia which was used. The results of the present investigation demonstrate that administration of 1,3-butanediol offers a novel approach for interfering with post-ischemic loss of CA1 neurons following a brief ischemic period which is effective even when initiated after prolonged recirculation periods.

• Authors: N R Sims, S L Heward
• Journal: Brain research (Brain Res) Vol. 662 Issue 1-2 Pg. 216-22 (Oct 31 1994) ISSN: 0006-8993 [Print] Netherlands
• PMID: 7859074 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetoacetates
• Butylene Glycols
• Hydroxybutyrates
• 1,3-butylene glycol
• acetoacetic acid
• 3-Hydroxybutyric Acid

Topics

• 3-Hydroxybutyric Acid
• Acetoacetates (metabolism)
• Animals
• Brain Ischemia (pathology)
• Butylene Glycols (pharmacokinetics, pharmacology)
• Cerebrovascular Circulation (drug effects, physiology)
• Hippocampus (pathology)
• Hydroxybutyrates (metabolism)
• Male
• Prosencephalon (blood supply, pathology)
• Pyramidal Cells (drug effects)
• Rats