Abstract |
We evaluated the rat cirrhosis model obtained by repeated intraperitoneal administration of CCl4 (group C) with regard to biological and nutritional conditions in comparison to ad libitum (group AL) and pair-fed control rats. Cirrhotic rats were divided into two groups according to their clinical condition: group C1 (n = 4) represented those in good physical condition and group C2 those (n = 10) in poor physical condition. Autopsy indicated that rats in group C2 suffered from severe malnutrition as judged by body weight, carcass weight and the carcass/ body weight ratio. However, all 14 treated rats presented the same micronodular cirrhosis and the same alterations in liver function, except for alkaline phosphatase activity (group C1: 110 +/- 63 IU/l, group C2: 259 +/- 110 IU/l; p < 0.05). In the cirrhosis groups, plasma levels of branched-chain amino acids (BCAA) and the BCAA/ aromatic amino acid (AAA) ratio were significantly reduced, but values in groups C1 and C2 were not significantly different (BCAA/AAA: 1.9 +/- 0.9 in group C1, 1.5 +/- 0.8 in group C2, 2.8 +/- 0.3 in group AL; C1 and C2, vs. AL: p < 0.05). These alterations were similar to those observed in human cirrhosis and were not solely the result of reduced food intake, as indicated by the lack of difference between pair-fed and ad libitum-fed control rats.
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Authors | F Blondé-Cynober, F Plassart, C Rey, C Coudray-Lucas, N Moukarbel, R Poupon, J Giboudeau, L Cynober |
Journal | Annals of nutrition & metabolism
(Ann Nutr Metab)
Vol. 38
Issue 4
Pg. 238-48
( 1994)
ISSN: 0250-6807 [Print] Switzerland |
PMID | 7832585
(Publication Type: Journal Article)
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Chemical References |
- Amino Acids
- Fatty Acids, Nonesterified
- Methylhistidines
- Triglycerides
- Fibrinogen
- Cholesterol
- Sodium
- Carbon Tetrachloride
- 3-methylhistidine
- Nitrogen
- Potassium
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Topics |
- Amino Acids
(blood, metabolism)
- Animals
- Carbon Tetrachloride
- Cholesterol
(blood)
- Disease Models, Animal
- Fatty Acids, Nonesterified
(blood)
- Fibrinogen
(metabolism)
- Liver
(metabolism, pathology)
- Liver Cirrhosis, Experimental
(chemically induced, metabolism, pathology)
- Male
- Methylhistidines
(urine)
- Nitrogen
(metabolism, urine)
- Potassium
(blood)
- Rats
- Rats, Sprague-Dawley
- Sodium
(blood)
- Triglycerides
(blood)
- Weight Gain
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