[Kaposi's disease in a female patient with acquired HIV-negative immunodeficiency].

Abstract

A 79-year-old woman of Mediterranean ascent suffered from corticosteroid-dependent chronic obstructive lung disease, hypogammaglobulinemia (IgG 1 and 2), decreased CD16 natural killer cell function and non-HIV related CD4 and CD8 lymphopenia. Such immunodeficiency could be either a variant of common variable immunodeficiency or an early stage of the idiopathic CD4 + T lymphocytopenia syndrome. She developed bilateral lesions of Kaposi's sarcoma on the lower extremities resembling the classic European type of the disease. The tumors contained both CD34 + and Factor XIIIa + cells. The HLA-DR5 haplotype was not found. Weekly low intravenous dosages of vinblastine improved the lesions but the patient died from pontic infarction.

• Authors: A F Nikkels, J Collignon, M P Moutschen, P Paquet, C Bouillenne, G E Piérard
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 23 Issue 38 Pg. 1760-1 (Dec 03 1994) ISSN: 0755-4982 [Print] France
• Vernacular Title: Maladie de Kaposi chez une patiente souffrant d'une immunodéficience acquise VIH négative.
• PMID: 7831265 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Methylprednisolone

Topics

• Aged
• Female
• HIV Seronegativity
• Humans
• Immunocompromised Host
• Immunologic Deficiency Syndromes (complications, immunology)
• Methylprednisolone (adverse effects)
• Sarcoma, Kaposi (etiology, immunology)