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Kaposi Sarcoma (Kaposi's Sarcoma)

A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
Also Known As:
Kaposi's Sarcoma; Sarcoma, Kaposi; Multiple Idiopathic Pigmented Hemangiosarcoma; Kaposis Sarcoma; Sarcoma, Kaposi's
Networked: 4000 relevant articles (254 outcomes, 386 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Acquired Immunodeficiency Syndrome (AIDS)
2. Neoplasms (Cancer)
3. Non-Hodgkin Lymphoma (Lymphosarcoma)
4. Melanoma (Melanoma, Malignant)
5. Ovarian Neoplasms (Ovarian Cancer)

Experts

1. Whitby, Denise: 38 articles (03/2022 - 01/2003)
2. Yarchoan, Robert: 37 articles (03/2022 - 03/2002)
3. Dezube, Bruce J: 30 articles (02/2014 - 01/2002)
4. Dittmer, Dirk P: 29 articles (01/2022 - 06/2003)
5. Bower, Mark: 28 articles (11/2021 - 11/2002)
6. Krown, Susan E: 26 articles (11/2020 - 01/2002)
7. Uldrick, Thomas S: 25 articles (03/2022 - 06/2011)
8. Schulz, Thomas F: 21 articles (01/2021 - 01/2002)
9. Marshall, Vickie: 18 articles (01/2020 - 01/2003)
10. Brambilla, Lucia: 17 articles (01/2022 - 05/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Kaposi Sarcoma:
1. liposomal doxorubicin (Doxil)FDA Link
2. Interferon-alpha (Interferon Alfa)IBA
3. Paclitaxel (Taxol)FDA LinkGeneric
4. Vincristine (Oncovin)FDA LinkGeneric
5. InterferonsIBA
6. Doxorubicin (Adriamycin)FDA LinkGeneric
7. Bleomycin (Blenoxane)FDA LinkGeneric
8. Zidovudine (Retrovir)FDA LinkGeneric
9. Sirolimus (Rapamycin)FDA Link
10. Vinblastine (Vinblastine Sulfate)FDA Link

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Highly Active Antiretroviral Therapy (HAART)
4. Radiotherapy
5. Aftercare (After-Treatment)