Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: Twenty of 46 patients responded to 2CdA therapy (43%; 95 CI; 29 to 60%) with a significantly higher frequency of benefit among patients with disease relapsing off therapy (78%) or with primary resistant disease within the first year (57%) than in those with later phases of disease (22%). The median survival after treatment was 28 months and the median progression-free survival of responding patients was 12 months. The longest survival was measured in patients with primary refractory disease (projected median 36 months) and the shortest in those with disease in refractory relapse (median 13 months). CONCLUSION:
2-Chlorodeoxyadenosine is active against macroglobulinemic lymphoma resistant to standard regimens and most effective in patients with disease relapsing off treatment or during the first year of primary refractory disease. Little benefit was observed among patients with later phases of resistant disease who should receive alternative treatments.
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Authors | M A Dimopoulos, D Weber, K B Delasalle, M Keating, R Alexanian |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 6
Issue 1
Pg. 49-52
(Jan 1995)
ISSN: 0923-7534 [Print] England |
PMID | 7710983
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Cladribine
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Middle Aged
- Neutropenia
(chemically induced)
- Prognosis
- Recurrence
- Remission Induction
- Survival Rate
- Waldenstrom Macroglobulinemia
(drug therapy, immunology, mortality)
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