Abstract | OBJECTIVES: METHODS: Stepwise increasing doses of cerulein (10-80 pmol/kg/h) were given i.v., each for 60 min with a secretin background (1 CU/kg/h). In the volunteer group, an additional experiment with infusion of placebo ( saline 0.9%) was performed. RESULTS: CCK-induced amino acid changes were small in volunteers (maximum decrease: 8.4 +/- 0.9%; mean +/- SEM), tended to be more pronounced in patients (maximum decrease: 13.8 +/- 2.8%; NS), and did not permit a distinction among volunteers and patients. There was no dose-response relationship between CCK and plasma amino acids in either group. In contrast, pancreatic polypeptide levels increased markedly and dose-dependently in volunteers and patients and tended to be lower in patients with pancreatic insufficiency. CONCLUSIONS:
|
Authors | J Borovicka, W Schwizer, B Remy, M Fried |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 90
Issue 7
Pg. 1111-5
(Jul 1995)
ISSN: 0002-9270 [Print] United States |
PMID | 7611207
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Amino Acids
- Pancreatic Polypeptide
- Ceruletide
|
Topics |
- Adult
- Aged
- Amino Acids
(blood)
- Ceruletide
- Exocrine Pancreatic Insufficiency
(diagnosis)
- Female
- Humans
- Male
- Middle Aged
- Pancreatic Polypeptide
(blood)
|