Abstract | BACKGROUND/AIMS: It has been suggested that activity of pancreatic enzymes and concentrations of tumoral markers in cyst fluid may help to distinguish pseudocyst, serous, and mucinous cystadenomas. The aim of this study was to prospectively assess the reliability of preoperative biochemical and tumor marker analysis in cyst fluids obtained by fine-needle aspiration for pathological diagnosis. METHODS: RESULTS:
Carbohydrate antigen 19.9 levels of > 50,000 U/mL had a 75% sensitivity and a 90% specificity for distinguishing mucinous tumors from other cystic lesions. Carcinoembryonic antigen levels of < 5 ng/mL had a 100% sensitivity and an 86% specificity for distinguishing serous cystadenomas from other cystic lesions. Amylase levels of > 5000 U/mL had a 94% sensitivity and a 74% specificity for distinguishing pseudocysts from other cystic lesions. CONCLUSIONS:
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Authors | P Hammel, P Levy, H Voitot, M Levy, V Vilgrain, M Zins, J F Flejou, G Molas, P Ruszniewski, P Bernades |
Journal | Gastroenterology
(Gastroenterology)
Vol. 108
Issue 4
Pg. 1230-5
(Apr 1995)
ISSN: 0016-5085 [Print] United States |
PMID | 7535275
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-19-9 Antigen
- Carcinoembryonic Antigen
- Lipase
- Amylases
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Topics |
- Amylases
(analysis)
- Biomarkers, Tumor
(analysis)
- Biopsy, Needle
- Body Fluids
(chemistry, immunology)
- CA-19-9 Antigen
(analysis)
- Carcinoembryonic Antigen
(analysis)
- Cystadenoma, Mucinous
(chemistry, diagnosis, immunology)
- Cystadenoma, Serous
(chemistry, diagnosis, immunology)
- Diagnosis, Differential
- Feasibility Studies
- Humans
- Lipase
(analysis)
- Pancreatic Cyst
(diagnosis, immunology, metabolism)
- Pancreatic Neoplasms
(chemistry, diagnosis, immunology)
- Pancreatic Pseudocyst
(chemistry, diagnosis, immunology)
- Predictive Value of Tests
- Prospective Studies
- Sensitivity and Specificity
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