Mucinous Cystadenoma

A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.

Also Known As:

Networked: 237 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Serous Cystadenoma
2.	Cysts
3.	Neoplasms (Cancer)
4.	Cystadenoma
5.	Ovarian Neoplasms (Ovarian Cancer)

Experts

1.	Linghu, Enqiang: 2 articles (01/2019 - 01/2017)
2.	Park, Ji Young: 2 articles (11/2015 - 11/2013)
3.	Couvelard, Anne: 2 articles (04/2014 - 06/2004)
4.	Ruszniewski, Philippe: 2 articles (04/2014 - 06/2004)
5.	Sauvanet, Alain: 2 articles (04/2014 - 06/2004)
6.	Qiu, Wanglong: 2 articles (05/2008 - 06/2006)
7.	Remotti, Helen E: 2 articles (05/2008 - 06/2006)
8.	Schönleben, Frank: 2 articles (05/2008 - 06/2006)
9.	Su, Gloria H: 2 articles (05/2008 - 06/2006)
10.	Tsunoda, Hajime: 2 articles (10/2004 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mucinous Cystadenoma:

1.	EnzymesIBA 04/01/1995 - "It has been suggested that activity of pancreatic enzymes and concentrations of tumoral markers in cyst fluid may help to distinguish pseudocyst, serous, and mucinous cystadenomas. " 01/01/1984 - "A study of the distribution of this enzyme in 50 primary ovarian neoplasms revealed its presence exclusively in mucinous and mixed (serous-mucinous) cystadenomas and cystadenocarcinomas. "
2.	Protons (Proton)IBA 01/01/2006 - "Proton MRS imaging may be helpful for the investigation of the underlying pathophysiology of ovarian mucinous cystadenomas."
3.	ParaffinIBA 01/01/1999 - "We analyzed 11 samples of pancreatic adenocarcinoma, three samples of pancreatic mucinous cystadenoma, and two samples without tumors in formalin-fixed paraffin embedded tissue sections. " 07/01/2005 - "Histologic sections of formalin-fixed, paraffin-embedded specimens from 11 patients with benign serous or mucinous cystadenomas, 14 patients with serous or mucinous borderline tumors, and 80 patients with epithelial-ovarian adenocarcinomas (29 serous, 17 endometrioid, 14 mucinous, and 20 clear cell adenocarcinomas) were stained for P-LAP and GLUT4 using each polyclonal antibody. " 01/01/1996 - "To establish a basis for the interpretation of DNA flow cytometric results of gynecologic neoplasms, paraffin blocks from 121 patients with a diagnosis of serous cystadenoma (n = 37), mucinous cystadenoma (n = 28), leiomyoma (n = 41), and fibrothecoma (n = 15), and normal tissue samples obtained from some of these patients, including ovary (n = 20), cervix (n = 20), and myometrium (n = 20) were analyzed for nuclear DNA content. " 04/01/2009 - "The study was performed on formalin-fixed, paraffin-embedded tissue samples from 75 epithelial ovarian tumors, 15 serous cystadenomas, 15 mucinous cystadenomas, 5 borderline serous cystadenomas, 5 borderline mucinous cystadenomas, 15 serous cystadenocarcinomas, 15 mucinous cystadenocarcinomas and 5 endometrioid carcinomas. " 01/01/1993 - "Nuclear DNA content in eight surgically resected mucin-producing pancreatic tumors (MPPT) consisting of two mucinous intraductal adenocarcinomas (MIDAC), two mucinous intraductal adenomas (MIDA), one mucinous cyst-adenocarcinoma (MCAC), and three mucinous cystadenomas (MCA) were measured by flow cytometry using paraffin-embedded tissue samples. "
4.	Carcinoembryonic AntigenIBA 01/01/2013 - "We report two patients presenting with mucinous cystadenoma of the appendix with elevation of serum carcinoembryonic antigen (CEA), which has rarely been reported. " 01/01/2013 - "Mucinous cystadenoma of the appendix presenting with an elevated carcinoembryonic antigen (CEA): Report of two cases and review of the literature." 11/01/2004 - "It is often difficult to discriminate GDC from pancreatic cystic tumour, in particular pancreatic mucinous cystadenoma, in which concentrations of carcinoembryonic antigen and CA 19-9 are classically raised. " 07/01/1997 - "Mucinous cystadenoma of the appendix with raised serum carcinoembryonic antigen concentration: clinical and pathological features." 04/01/1998 - "Combined measurement of CA 72-4 and carcinoembryonic antigen may be used to distinguish accurately mucinous cystadenomas and cystadenocarcinomas from serous cystadenomas and pseudocysts."
5.	Formaldehyde (Formol)FDA Link 01/01/1999 - "We analyzed 11 samples of pancreatic adenocarcinoma, three samples of pancreatic mucinous cystadenoma, and two samples without tumors in formalin-fixed paraffin embedded tissue sections. " 07/01/2005 - "Histologic sections of formalin-fixed, paraffin-embedded specimens from 11 patients with benign serous or mucinous cystadenomas, 14 patients with serous or mucinous borderline tumors, and 80 patients with epithelial-ovarian adenocarcinomas (29 serous, 17 endometrioid, 14 mucinous, and 20 clear cell adenocarcinomas) were stained for P-LAP and GLUT4 using each polyclonal antibody. " 04/01/2009 - "The study was performed on formalin-fixed, paraffin-embedded tissue samples from 75 epithelial ovarian tumors, 15 serous cystadenomas, 15 mucinous cystadenomas, 5 borderline serous cystadenomas, 5 borderline mucinous cystadenomas, 15 serous cystadenocarcinomas, 15 mucinous cystadenocarcinomas and 5 endometrioid carcinomas. "
6.	Tumor Biomarkers (Tumor Markers)IBA 06/01/2004 - "The aim of this study was to determine the EUS and tumor marker characteristics of mucinous cystadenoma compared with macrocystic serous cystadenomas. " 03/01/1995 - "To present knowledge, this is the first reported case with extremely high serum tumor markers in a postmenopausal woman with torsion of a stage-Ia ovarian mucinous cystadenoma of borderline malignancy. "
7.	Proliferating Cell Nuclear Antigen (PCNA)IBA 11/01/1995 - "Mucinous cystadenoma of the lung appears to be a benign neoplasm because of its clinical course and immunohistochemical low expression of proliferation markers such as PCNA and MIB1." 11/01/1995 - "This study of two cases was performed to characterize mucinous cystadenoma clinically and immunohistochemically, using proliferation markers (proliferating cell nuclear antigen [PCNA], MIB1) and carcinoembryonic antigen expression. "
8.	LDL Receptors (LDL Receptor)IBA 07/01/2000 - "Immunohistochemical studies of these mucinous cystadenomas showed that LDL receptors were distributed in the benign cystadenoma cells and in the stromal cells of borderline tumors, but not in the cystadenoma cells of borderline tumors. "
9.	stage-specific embryonic antigen-4IBA 08/01/2010 - "In this study, we investigated the expression of SSEA-4 in 479 cases of various degrees of ovarian epithelial lesions by immunohistochemistry, consisting of 45 normal ovarian epithelia, 110 benign serous ovarian cystadenomas, 68 borderline serous ovarian cystadenomas, 104 invasive serous ovarian carcinomas, 64 benign serous mucinous cystadenomas, 48 borderline mucinous ovarian cystadenomas, and 40 invasive mucinous carcinomas. "
10.	fascinIBA 01/01/2006 - "In the study, 94 malign epithelial ovarian neoplasms, 13 borderline epithelial ovarian neoplasms, 25 serous and mucinous cystadenomas and four normal ovarian tissues were examined by means of immunohistochemistry, using monoclonal antihuman fascin antibody, clone IM20. "

Therapies and Procedures

1.	Laparotomy 02/01/2012 - "The diagnosis of mucinous cystadenomas of the mesocolon is challenging due to the absence of specific clinical, biological and radiological features, and is often made during or after laparotomy. " 01/01/2012 - "A preoperative diagnosis of mucinous cystadenoma of the pancreas was suggested and the patient underwent laparotomy. " 05/07/2010 - "She underwent laparotomy and after surgical removal, the mass was found to be mucinous cystadenoma on histology." 08/30/2008 - "A mucinous cystadenoma of the ovary weighing more than 20 kg was removed with laparotomy. " 06/01/1988 - "At laparotomy, a large mucinous cystadenoma was found attached to the root of the ileal mesentery; the ovaries were normal. "
2.	Conservative Treatment 09/15/2002 - "Conservative management is wholly justified for serous cystadenoma without complications, whereas mucinous cystadenoma can be cured by pancreatic resection. " 05/01/2000 - "Some lesions are benign (pseudocyst, serous cystadenoma) requiring conservative management and follow-up, whereas others are premalignant (mucinous cystadenoma, intraductal papillary mucinous tumor.) or frankly malignant (cystadenocarcinoma) and require surgical resection when possible. " 05/09/1980 - "These methods, localizing the source of ectopic gastrin, permitted conservative management of the ulcer diathesis with surgical resection of the mucinous cystadenoma. "
3.	Cystectomy 10/01/2020 - "Two patients underwent laparoscopic ovarian cystectomy for mucinous cystadenoma. " 10/01/2020 - "We present 2 cases of progression from mucinous cystadenoma to mucinous BOT (mBOT) after prior cystectomies in whom an AI was used with recurrence prevention. " 06/01/2018 - "Follow-up of these patients is very important and transvaginal ultrasound seems to be currently the most effective diagnostic tool for the follow-up of young patients treated with cystectomy for benign mucinous cystadenomas. " 06/01/2018 - "Recurrent Bilateral Mucinous Cystadenoma: Laparoscopic Ovarian Cystectomy with Review of Literature." 05/01/2015 - "We conducted a retrospective analysis of all cases of patients who underwent removal of benign mucinous cystadenomas by either cystectomy or adnexectomy in our institution between December 2006 and June 2013. "
4.	Appendectomy 03/01/2023 - "Laparoscopic appendectomy is a common approach worldwide and can be used in the management of mucinous cystadenoma with lower postoperative complication rates. " 01/01/2019 - "[Laparoscopic appendectomy for mucinous cystadenoma of the appendix]." 11/01/2016 - "We report a case of mucinous cystadenoma of the appendix treated using laparoscopy-assisted appendectomy and discuss the case with literature reviews." 11/01/2016 - "[A Case of Appendiceal Mucinous Cystadenoma Treated Using Laparoscopic Appendectomy]." 01/01/2016 - "2 synchronous appendiceal pathologies (mucinous cystadenomas of the appendix) were defined in appendectomies performed. "
5.	Pancreatectomy 01/01/2021 - "Laparoscopic distal pancreatectomy was performed, and the resected specimen was diagnosed with mucinous cystadenoma. " 06/01/2012 - "We report the case of a 72-year-old female patient with a mucinous cystadenoma, who was found to have a concomitant AP during laparoscopic distal pancreatectomy. " 01/01/2004 - "In January 2002, the patient underwent a spleen-preserving distal pancreatectomy, and histopathological and immunohistochemical examinations led to the diagnosis of pancreatic mucinous cystadenoma with ovarian-like stroma. " 11/01/1998 - "After distal pancreatectomy the diagnosis of mucinous cystadenoma was confirmed; in one case a large pseudocyst was associated with this diagnosis. " 01/01/1988 - "Surgical resection is the method to be chosen, either enucleation (1 case) or pancreatectomy (3 cases), being more important in mucinous cystadenoma because they may become malignant. "