| Abstract | By blocking the inward transmembrane calcium current and opposing the effects of increased intracellular ionised calcium, calcium antagonists exert vascular and myocardial effects which are useful therapeutic tools. Coronary and peripheral vascular relaxation results in an increase in coronary flow and a reduction of the afterload and, therefore, of myocardial oxygen consumption. In some cases, negative myocardial inotropic and chronotropic effects also reduce myocardial oxygen requirements. Spastic angina is the indication of choice of all calcium antagonists whereas, to date, verapamil and diltiazem have been shown to be effective in stable angina and, in the post-infarction situation, diltiazem and verapamil decrease the number of cardiovascular events, and verapamil alone has been shown to reduce mortality. All calcium antagonists have been shown to be effective in hypertension and most have a protective effect on the target organs. The main fields of research concern atherosclerosis, the primary prevention of myocardial infarction and the study of molecules which can be used in heart failure. |
| Authors | C Thuillez
(Affiliation: Service de pharmacologie, CHU de Rouen.)
|
| Journal | Archives des maladies du coeur et des vaisseaux
(Arch Mal Coeur Vaiss)
Vol. 88 Spec No 4
Pg. 9-12
(Sep 1995)
ISSN: 0003-9683 FRANCE |
| Vernacular Title | Antagonistes calciques en pathologie cardiovasculaire. |
| PMID | 7503623
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
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| Topics |
- Animals
- Calcium Channel Blockers
(therapeutic use)
- Cardiovascular Diseases
(drug therapy)
- Humans
- Hypertension
(drug therapy)
- Myocardial Ischemia
(drug therapy)
|
