Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor.

Abstract

Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substantially alter the chemotactic activity of human eosinophils. The cellular mechanism whereby ECF-A tetrapeptides enhance IgG-dependent killing of schistosomula by rat eosinophils is, however, unclear. We now report that the parent tetrapeptides and the substituted analogue Val-Pro-Ser-Glu (Pro3), but not histamine, increase the number of rat and human eosinophils that form rosettes with erythrocytes bearing IgG antibodies. Moreover, we find a correlation between the effect of these substances on the expression of rat eosinophil IgG Fc receptors and their capacity to increase the IgG-dependent cytotoxicity of rat eosinophils for Schistosoma mansoni schistosomula.

• Authors: M Capron, A Capron, E J Goetzl, K F Austen
• Journal: Nature (Nature) Vol. 289 Issue 5793 Pg. 71-3 (Jan 01 1981) ISSN: 0028-0836 [Print] England
• PMID: 7453810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemotactic Factors
• Chemotactic Factors, Eosinophil
• Oligopeptides
• Receptors, Fc
• Histamine

Topics

• Animals
• Chemotactic Factors (pharmacology)
• Chemotactic Factors, Eosinophil (pharmacology)
• Chemotaxis, Leukocyte
• Eosinophils (physiology)
• Histamine (pharmacology)
• Mast Cells (physiology)
• Neutrophils (immunology)
• Oligopeptides (pharmacology)
• Rabbits
• Rats
• Receptors, Fc (drug effects)
• Rosette Formation