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Fc Receptors (Fc Receptor)

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Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Also Known As:

Fc Receptor; Receptors, Fc; Receptor, Fc

Networked: 1112 relevant articles (32 outcomes, 100 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Takai, Toshiyuki: 15 articles (01/2008 - 02/2002)
2.	Ravetch, Jeffrey V: 10 articles (09/2008 - 06/2002)
3.	Verbeek, J Sjef: 7 articles (09/2009 - 10/2002)
4.	Nimmerjahn, Falk: 6 articles (12/2009 - 03/2006)
5.	van de Winkel, J G: 6 articles (10/2001 - 04/2000)
6.	Weng, Wen-Kai: 5 articles (01/2010 - 12/2004)
7.	Schmidt, Reinhold E: 5 articles (12/2009 - 01/2003)
8.	Gessner, J Engelbert: 5 articles (12/2009 - 01/2003)
9.	Kleinau, Sandra: 5 articles (08/2008 - 10/2002)
10.	Nakamura, Akira: 5 articles (01/2008 - 02/2002)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1996 - "These results showed that, even though the bivalent mAb 1.1ASML did not mediate stable cross-linking of target and effector cells, its Fc-receptor-mediated killing of tumor cells was more effective when compared to the BAC. " 11/15/1990 - "and decreased Fc receptor-mediated binding, demonstrated improved tumor:tissue ratios as compared to intact antibody HA. " 11/15/1987 - "Overall, these studies have demonstrated the specificity of Fc receptors in triggering monocyte- and granulocyte-mediated antibody-dependent tumor cell killing and have begun to dissect functional similarities and differences among the three defined Fc gamma R on human myeloid cells." 12/01/2008 - "Augmentation of T-cell responses is dependent on the presence of tumor as well as on activating Fc receptors. " 12/01/2004 - "In a redirected lysis assay, preincubation of the effector cells with WEN23 augmented lysis of the Fc receptor (FcR)+ murine tumor target cells, indicating that NKp46 is an activating NK cell receptor. " Order ALL the reference details at left...
2.	Infection 06/15/2001 - "Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections." 02/01/1989 - "Thus, the Fc receptor is an attractive candidate for application in the diagnosis of, or protection against, infections with S. " 06/15/2001 - "We conclude that Fc receptor-mediated phagocytosis plays a pivotal role in clearance of respiratory virus infections." 04/01/1993 - "Infection of primary macrophages in vitro by feline infectious peritonitis virus (FIPV) was used as a model system to study the kinetics of Fc receptor-mediated antibody-dependent enhancement (FcR-ADE) of virus infectivity at the single cell level. " 03/01/1992 - "Studies of antibody-dependent enhancement of human immunodeficiency virus (HIV) type 1 infection mediated by Fc receptors using sera from recipients of a recombinant gp160 experimental HIV-1 vaccine." Order ALL the reference details at left...
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/1987 - "Reticuloendothelial system Fc receptor function in systemic lupus erythematosus: effect of decreased sensitization on clearance of autologous erythrocytes." 12/01/1989 - "Nuclear imaging and the assessment of human Fc receptor function: studies in systemic lupus erythematosus." 02/01/1983 - "Studies in patients with active systemic lupus erythematosus show a profound defect in Fc-receptor-specific clearance that correlates with disease activity. " 01/01/1982 - "A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). " 01/01/1982 - "A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus." Order ALL the reference details at left...
4.	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 08/01/1995 - "Expression, saturation, and endocytosis of IgA Fc receptors (Fc alpha R) were analyzed in blood phagocytic cells of patients with alcoholic liver cirrhosis (ALC). " 08/01/1995 - "Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis. " 04/01/1985 - "Twenty-one patients with primary IgA nephropathy, 7 patients with Henoch-Schönlein nephritis and 4 patients with IgA nephropathy associated to alcoholic liver cirrhosis were tested for Fc-receptor phagocyte function by measuring the clearance of radiolabelled IgG-sensitized erythrocytes in vivo and the immune phagocytosis by monocytes in vitro. " 10/01/1991 - "Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). " 01/01/1985 - "The number of C3b receptors detected on 100 monocytes was significantly lower in patients with primary biliary cirrhosis (23.0 +/- 12.0, mean +/- 1 SD) compared with normal controls (57.4 +/- 16.9) and other chronic liver disease (HBsAg negative chronic active hepatitis 62.0 +/- 17.0, alcoholic cirrhosis 50.9 +/- 4.0), while the number of Fc receptors detected on 100 monocytes was not significantly different in all the groups (primary biliary cirrhosis 72.8 +/- 28.6, chronic active hepatitis 74.7 +/- 14.0, alcoholic cirrhosis 58.0 +/- 13.5 and normal controls 69.6 +/- 19.9). " Order ALL the reference details at left...
5.	Autoimmune Diseases (Autoimmune Disease) 08/15/2005 - "Genetic studies in mice indicate a crucial role for Fc receptors (FcR) in antibody-mediated autoimmune diseases. " 07/01/2005 - "While the recognition site on Fab is unknown, comparative binding studies with Fc, in association with the striking similarities of the peptide (named Fc-receptor mimetic, FcRM) with a region of the human FcgammaRIII receptor, strongly indicate that the peptide could recognize a short amino acid stretch of the lower hinge region, which has a key role in autoimmune disease triggering. " 01/01/1985 - "In vitro study of Fc-receptor function in autoimmune diseases." 11/01/2009 - "A polymorphism that up-regulates the expression of Fc receptor-like 3 (FCRL3) gene has recently been described as predisposing for several human autoimmune diseases. " 01/01/2009 - "PURPOSE: The polymorphisms of the Fc receptor-like 3 gene (FCRL3), a novel immunoregulatory gene, have been shown to be associated with certain autoimmune diseases. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antigen-Antibody Complex (Immune Complex)
3.	Antibodies
4.	Immunoglobulin E (IgE)
5.	tranilast (N 5')
6.	Antigens
7.	rituximab (Mabthera)
8.	trastuzumab (Herceptin)
9.	Suspensions
10.	Interleukin-2 (IL2)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Immunotherapy
3.	Ligation
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Drug Therapy (Chemotherapy)

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