Abstract |
The therapeutic efficacy and upper limits of corticosteroid dosage in the treatment of collagen diseases have not been determined. Thirteen patients are reported (11 with systemic lupus erythematosus, 2 with polymyositis), 7 of whom had good clinical results from megadose dexamethasone therapy in the range of 1,300 to 7,200 mg during an acute stage of their disease. Of the 7, 5 patients also had improved laboratory findings; 3 also had improved radiolgic abnormalities. Complications seem no worse than from conventional high-dosage corticosteroid therapy.
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Authors | W J Fessel |
Journal | The Journal of rheumatology
(J Rheumatol)
1980 Jul-Aug
Vol. 7
Issue 4
Pg. 486-500
ISSN: 0315-162X [Print] Canada |
PMID | 7420330
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adrenal Cortex Hormones
(administration & dosage, adverse effects, therapeutic use)
- Adult
- Child
- Dose-Response Relationship, Drug
- Encephalitis
(drug therapy)
- Female
- Humans
- Lupus Erythematosus, Systemic
(drug therapy)
- Male
- Middle Aged
- Myositis
(drug therapy)
- Nephritis
(drug therapy)
- Pneumonia
(drug therapy)
- Thrombocytopenia
(drug therapy)
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