Detection of sclerosis-inducing glycosaminoglycan in the skin of an amine-induced experimental skin sclerosis.

Abstract

The presence of sclerosis-inducing glycosaminoglycan in the skin was confirmed in an experimental skin sclerosis induced by a chemical compound. An experimental skin sclerosis was first produced in the mouse with bis(4-amino-3-methylcyclohexyl)methane. Out of glycosaminoglycans isolated from the slightly changed skin of this experimental skin sclerosis, the one having a heparan sulfate-like structure was able to again induce sclerotic skin changes in another mouse. The chemical composition of this sclerosis-inducing glycosaminoglycan was somewhat similar to that of the scleroderma-inducing glycosaminoglycan isolated previously from the urine of patients with systemic scleroderma.

• Authors: H Ishikawa, A Yamakage, M Kitabatake, H Katayama, Y Saito
• Journal: Dermatologica (Dermatologica) Vol. 161 Issue 3 Pg. 145-51 ( 1980) ISSN: 0011-9075 [Print] Switzerland
• PMID: 7398992 (Publication Type: Journal Article)

Chemical References

• Cyclohexylamines
• Glycosaminoglycans
• bis(4-amino-3-methylcyclohexyl)methane

Topics

• Animals
• Cyclohexylamines
• Glycosaminoglycans (isolation & purification, toxicity)
• Male
• Mice
• Scleroderma, Systemic (chemically induced, physiopathology)
• Skin (analysis)