The antimicrobial effectiveness of operative-site preparative agents: a microbiological and clinical study.

Abstract

Eight wound preparative agents (one triclosan compound, one hexachlorophene compound, and six iodophors) were evaluated under actual operating-room conditions for efficacy in de-germing the operative site prior to the performance of 310 total hip arthroplasties. All of the preparations tested achieved a significant reduction (p less than or equal to 0.001) of indigenous skin microflora compared with the pre-scrub level in both the post-scrub and the postoperative cultures. Two iodophors, when applied as sprays, demonstrated excellent bactericidal action, were less time-consuming and easier to use than the compounds that were applied as scrubs, and did not alter the low (0.42 per cent) infection rate that we have recorded over a period of four years.

• Authors: M A Ritter, M L French, H E Eitzen, T J Gioe
• Journal: The Journal of bone and joint surgery. American volume (J Bone Joint Surg Am) Vol. 62 Issue 5 Pg. 826-8 (Jul 1980) ISSN: 0021-9355 [Print] United States
• PMID: 7391106 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Infective Agents, Local
• Iodophors
• Triclosan
• Iodine
• Hexachlorophene

Topics

• Anti-Infective Agents, Local (pharmacology)
• Bacteria (isolation & purification)
• Disinfection
• Hexachlorophene (pharmacology)
• Hip Joint (surgery)
• Humans
• Iodine (pharmacology)
• Iodophors (pharmacology)
• Preoperative Care
• Skin (drug effects, microbiology)
• Sterilization
• Surgical Wound Infection (prevention & control)
• Triclosan (pharmacology)