Abstract |
Gastric inhibitory polypeptide (GIP) release into the portal vein in response to duodenal instillation of glucose in doses of 0.695, 1.39, 2.78 and 5.56 mmol/kg body weight was studied in an acute condition in male Wistar rats. A rapid, dose-dependent, and significant rise in portal vein plasma GIP was found in response to increasing duodenal glucose loads, which could be described by Michaelis-Menten kinetics. It is suggested that the glucose-induced GIP release into the portal vein mainly is effected first after glucose has gained access inside the mucosal cells.
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Authors | T B Schulz, P G Burhol, R Jorde, H L Waldum |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 16
Issue 8
Pg. 1061-5
( 1981)
ISSN: 0036-5521 [Print] England |
PMID | 7336132
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gastrointestinal Hormones
- Gastric Inhibitory Polypeptide
- Glucose
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Topics |
- Animals
- Dose-Response Relationship, Drug
- Duodenum
(metabolism)
- Gastric Inhibitory Polypeptide
(blood)
- Gastrointestinal Hormones
(blood)
- Glucose
(pharmacology)
- Kinetics
- Male
- Portal Vein
(metabolism)
- Rats
- Rats, Inbred Strains
- Time Factors
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