Cycloheximide treatment modifies the pattern of "metastasis" following intravenous injection of Ehrlich ascites tumour cells.

Cyclohexamide treatment of recipient mice at various times in relation to an intravenous injection of Ehrlich ascites tumor cells alters the pattern of consequent "metastatic" disease as compared with the pattern in untreated, tumour-injected animals. Analysis of the results suggests the existence of a cycloheximide-sensitive host mechanism for eliminating arrested tumour cells. This mechanism could play an important role in determining the ultimate localisation pattern of neoplastic disease following an intravenous injection of Ehrlich tumour cells.
AuthorsE W Parry
JournalGan (Gan) Vol. 72 Issue 3 Pg. 464-7 (Jun 1981) ISSN: 0016-450X [Print] JAPAN
PMID7319203 (Publication Type: Journal Article)
Chemical References
  • Cycloheximide
  • Animals
  • Carcinoma, Ehrlich Tumor (pathology)
  • Cycloheximide (pharmacology)
  • Female
  • Injections, Intravenous
  • Liver Neoplasms (secondary)
  • Male
  • Mice
  • Mice, Inbred CBA
  • Neoplasm Metastasis
  • Neoplasm Transplantation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: