Brain monoamine oxidase and replacement of its coenzyme flavin in rats.

Abstract

The influence of 7-ethyl-8-methylflavin and 7-methyl-8-ethylflavin, vitamin-like homologues of riboflavin, on rat brain mitochondrial monoamine oxidase (MAO) was studied using tyramine as substrate. While riboflavin deficiency caused the enzyme activity to fall to 80% of norma, when 7-ethyl-8-methylflavin replaced riboflavin as the precursor of its coenzyme, it caused essentially complete loss of the enzyme activity. We showed that while 7-ethyl-8-methylflavin can serve as a coenzyme for MAO, 7-methyl-8-ethylflavin cannot serve as coenzyme for this enzyme.

• Authors: B A Dix, J P Lambooy
• Journal: The Journal of nutrition (J Nutr) Vol. 111 Issue 8 Pg. 1397-402 (Aug 1981) ISSN: 0022-3166 [Print] United States
• PMID: 7264772 (Publication Type: Journal Article)

Chemical References

• 7-ethyl-8-methylflavin
• Coenzymes
• 7-methyl-8-ethylflavin
• Monoamine Oxidase
• Riboflavin
• Tyramine

Topics

• Animals
• Brain (drug effects, enzymology)
• Coenzymes (pharmacology)
• Female
• Kinetics
• Mitochondria (enzymology)
• Monoamine Oxidase (metabolism)
• Rats
• Riboflavin (analogs & derivatives, pharmacology)
• Riboflavin Deficiency (enzymology)
• Tyramine (metabolism)