Safety and efficacy of netilmicin in neonates with serious systemic infections.

Abstract

Twenty-five hospitalized neonates, each with two or more serious symptomatic infections, were given netilmicin by intramuscular injection. The antibiotic was administered usually at 1.5 or 3.0 mg/kg twice a day (q 12 hr) for 7 to 13 days. At the end of therapy the signs and symptoms of infection were completely resolved in twenty-four of the twenty-five patients and markedly improved in the remaining one. Thirty-five causative organisms were isolated from 30 of the 59 infection sites; after netilmicin therapy 31 causative organisms were completely eliminated and 4 were markedly reduced in number. One of the babies had a slight increase in serum creatinine level, possibly related to therapy, and a mild transient rash which was doubtfully related to netilmicin. None of the other neonates had adverse reactions.

• Authors: H Trujillo, R Manotas, J Loaiza
• Journal: The Journal of international medical research (J Int Med Res) Vol. 9 Issue 1 Pg. 52-7 ( 1981) ISSN: 0300-0605 [Print] England
• PMID: 7202831 (Publication Type: Journal Article)

Chemical References

• Gentamicins
• Netilmicin

Topics

• Bacterial Infections (drug therapy, microbiology)
• Female
• Gentamicins (therapeutic use)
• Humans
• Infant, Newborn
• Infant, Newborn, Diseases (drug therapy)
• Male
• Netilmicin (adverse effects, therapeutic use)