Nephrotoxicity following acute administration of N-(3,5-dichlorophenyl)succinimide in rats.

Abstract

The acute renal effects of the fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) were studied in male Sprague-Dawley rats. NDPS (50 mg/kg, i.p.) increased urine volume and decreased food intake and body weight at 24 h but not 48 h. No change in urine content or the accumulation by renal cortical slices of the organic anion p-aminohippurate (PAH) or the organic cation tetraethylammonium (TEA) was observed with 50 mg/kg NDPS when compared to control animals. Rats receiving 100 or 200 mg/kg NDPS (i.p.) exhibited increased urine volume, proteinuria, glucosuria, decreased food intake and body weight, increased BUN and decreased accumulation of PAH and TEA at both 24 h and 48 h. These effects were generally more pronounced at the 200 mg/kg dose level. Pair-fed control experiments demonstrated that renal effects were NDPS-induced and not related to daily food consumption. NO change in water intake was observed with any dose of NDPS used. The results demonstrate that NDPS alters renal function in a dose-dependent manner. In addition, NDPS (50 mg/kg) is capable of producing diuresis without apparent nephrotoxicity while doses of 100 mg/kg or more produce diuresis and nephrotoxicity.

• Authors: G O Rankin
• Journal: Toxicology (Toxicology) Vol. 23 Issue 1 Pg. 21-31 ( 1982) ISSN: 0300-483X [Print] Ireland
• PMID: 7089982 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fungicides, Industrial
• Succinimides
• N-(3,5-dichlorophenyl)succinimide

Topics

• Animals
• Blood Urea Nitrogen
• Body Weight (drug effects)
• Eating (drug effects)
• Fungicides, Industrial (toxicity)
• In Vitro Techniques
• Kidney (metabolism)
• Kidney Cortex (metabolism)
• Kidney Diseases (chemically induced, urine)
• Male
• Rats
• Rats, Inbred Strains
• Succinimides (toxicity)