Hepatic veno-occlusive disease caused by 6-thioguanine.

Abstract

Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related solely to 6-thioguanine.

• Authors: R A Gill, G R Onstad, J M Cardamone, D C Maneval, H W Sumner
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 96 Issue 1 Pg. 58-60 (Jan 1982) ISSN: 0003-4819 [Print] United States
• PMID: 7053705 (Publication Type: Case Reports, Journal Article)

Chemical References

• Thioguanine

Topics

• Adult
• Hepatic Veins
• Humans
• Leukemia, Lymphoid (drug therapy)
• Liver (pathology)
• Male
• Thioguanine (adverse effects)
• Vascular Diseases (chemically induced, pathology)