[Fenquizone in the medium term treatment of essential hypertension. Double-blind comparison with chlorthalidone and placebo].

Abstract

In a double blind study, tolerability and antihypertensive effect of fenquizone were compared with those of chlorthalidone and placebo. In both mild and moderately severe essential hypertension, fenquizone and chlortalidone showed a significant antihypertensive effect; moreover, fenquizone lowered the clinostatic arterial diastolic pressure in a more gradual and continuous way. Differently from chlortalidone, fenquizone had no effects on blood levels of potassium and cholesterol.

• Authors: C Pasotti, R Rossi, P Gandolfi
• Journal: Minerva medica (Minerva Med) Vol. 72 Issue 46 Pg. 3105-10 (Nov 17 1981) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: I fenquizone nel trattamento a medio termine dell'ipertensione arteriosa essenziale. Confronto in doppio cieco con clortalidone e placebo.
• PMID: 7029355 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Placebos
• Quinazolines
• fenquizone
• Chlorthalidone
• Potassium

Topics

• Adult
• Aged
• Blood Pressure (drug effects)
• Chlorthalidone (therapeutic use)
• Clinical Trials as Topic
• Diuresis (drug effects)
• Double-Blind Method
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged
• Placebos
• Potassium (urine)
• Quinazolines (therapeutic use)