Doxpicomine in postoperative pain.

Abstract

In a single-dose study the analgesic activity of 400 mg doxpicomine was compared with 4 and 8 mg morphine administered intramuscularly. Our subjects wee 43 men with moderate or severe postsurgical pain on the first postoperative day. Results of a double-blind trial indicate the analgesic activity of 400 mg intramuscular doxpicomine to be within the range of 8 mg morphine. There was no statistical significance between the effects of 400 mg doxpicomine and 8 mg morphine with the exception of half-hour data where doxpicomine was more effective than morphine. Doxpicomine has a rapid onset of analgesic action, the duration of which is equivalent to that of 8 mg morphine.

• Authors: R I Wang, N Robinson
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 29 Issue 6 Pg. 771-5 (Jun 1981) ISSN: 0009-9236 [Print] United States
• PMID: 7014073 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Analgesics
• Dioxanes
• Pyridines
• Morphine
• doxpicodin

Topics

• Adult
• Aged
• Analgesics (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Dioxanes (therapeutic use)
• Humans
• Male
• Middle Aged
• Morphine (therapeutic use)
• Pain, Postoperative (drug therapy)
• Pyridines (therapeutic use)