General practitioners' evaluation of side-effects and efficacy of oxamethacin as compared with indomethacin.

Abstract

Sixteen general practitioners conducted a multicentre double-blind clinical trial to compare oxamethacin (100 mg t.i.d.) with indomethacin (50 mg t.i.d.) for a maximum duration of 2 weeks. Each drug was administered to 339 patients suffering from various pathological conditions requiring a non-steroidal anti-inflammatory drug. When focusing on patients without associated drug therapy, 126/259 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p less than 10(-2)); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p less than 5.10(-2)). Side effects and complaints were reported by 34/250 patients (14%) under oxamethacin and by 67/236 (28%) under indomethacin (p less than 5.10(-5)). Some patients stopped treatment because of side-effects: 14/250 (6%) under oxamethacin and 32/236 (14%) under indomethacin (p less than 2.10(-3)).

• Authors: J Polderman, M Colon
• Journal: The Journal of international medical research (J Int Med Res) Vol. 8 Issue 2 Pg. 156-62 ( 1980) ISSN: 0300-0605 [Print] England
• PMID: 6989685 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Capsules
• oxamethacin
• Indomethacin

Topics

• Analysis of Variance
• Capsules
• Clinical Trials as Topic
• Digestive System (drug effects)
• Double-Blind Method
• Female
• Humans
• Indomethacin (adverse effects, analogs & derivatives, therapeutic use)
• Inflammation (drug therapy)
• Male
• Middle Aged
• Nervous System (drug effects)
• Physicians, Family