Pharmacological and toxicological studies of a new non-steroidal anti-inflammatory drug: KC-8973.

Abstract

A benzophenone derivative, 4-butyl-2'-fluorobenzophenone (KC-8973), having anti-inflammatory effects has been studied pharmacologically and toxicologically. On the carrageenin-induced paw edema, KC-8973 had the most potent activity of the tested commercial non-steroidal anti-inflammatory drugs. KC-8973 had a moderate effect on bradykinin-induced capillary permeability and lesser effect on dextran-, egg white- and serotonin-induced paw edemas in rats, respectively. From the detailed studies of prophylactic and therapeutic effects on the adjuvant-induced arthritis in rats, it was demonstrated that KC-8973 has an immuno-suppressive activity in addition to an anti-inflammatory effect. KC-8973 had a local-analgesic and antipyretic effect on the rat paw edema induced by brewer's yeast. KC-8973 caused no undesirable side effect at pharmacologically effective dose in the 1-month sub-acute toxicological study.

• Authors: T Matsuo, K Amemiya, K Saga, Y Hamazaki, M Tanaka, T Kato
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 31 Issue 7 Pg. 1105-10 ( 1981) ISSN: 0004-4172 [Print] Germany
• PMID: 6973993 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Benzophenones
• 4-butyl-2'-fluorobenzophenone

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology, toxicity)
• Anti-Inflammatory Agents, Non-Steroidal
• Benzophenones (pharmacology, toxicity)
• Capillary Permeability (drug effects)
• Male
• Rats