Abstract |
To assess Leydig cell function in men with idiopathic oligospermia, serum levels of testosterone and 17-hydroxyprogesterone were measured before and after the administration of human chorionic gonadotopin (hCG) to men with oligospermia (< 20 x 10(6) sperm/ml). Serum testosterone and 17-hydroxyprogesterone levels, both basally and after 2 or 72 hours of hCG stimulation of Leydig cell output, were the same in the oligospermic and control groups, although basal serum testosterone levels correlated directly with sperm density (r = 0.34; P < 0.05). The basal serum level of luteinizing hormone (LH) was slightly but significantly higher in the oligospermic group than in the control group (12.0 +/- 1.0 [SE] mIU/ml versus 9.5 +/- 0.5; P < 0.05), as was the LH: testosterone ratio (2.45 +/- 0.20 versus 1.74 +/- 0.20; P < 0.02). The combination of slightly elevated serum LH levels with unchanged basal serum levels of gonadal steroids suggests that men with idiopathic oligospermia have a mild, compensated Leydig cell defect. The mildness of this defect is reflected by the ability of maximal gonadotropic stimulation to increase androgen output.
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Authors | A R Glass, R A Vigersky |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 34
Issue 2
Pg. 144-8
(Aug 1980)
ISSN: 0015-0282 [Print] United States |
PMID | 6773819
(Publication Type: Journal Article)
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Chemical References |
- Chorionic Gonadotropin
- Hydroxyprogesterones
- Testosterone
- Estradiol
- Prolactin
- Follicle Stimulating Hormone
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Topics |
- Adult
- Chorionic Gonadotropin
(pharmacology)
- Estradiol
(blood)
- Follicle Stimulating Hormone
(blood)
- Humans
- Hydroxyprogesterones
(blood)
- Leydig Cells
(physiopathology)
- Male
- Oligospermia
(physiopathology)
- Prolactin
(blood)
- Testosterone
(blood)
- Time Factors
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