[Body temperature and the reaction to pyrogenal in germ-free and ordinary animals].

Abstract

Body temperature, as well as pyrexia in response to pyrogenal in germfree and conventional mice and miniature piglets were studied. A decrease of the mean body temperature in the intact germ-free mice and miniature piglets in comparison with conventional animals of the corresponding species was revealed. The absence of marked pyretic response to pyrogenal after intraperitoneal injections of 10 minimal pyrogenic doses to mice and after intramuscular injections of 500 minimal pyrogen doses of pyrogenal to miniature piglets was observed in germfree animals. The data obtained indicated an important role of autoflora in the development of the organism capacity to temperature reaction and pyrexia.

• Authors: G I Podoprigora
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 85 Issue 3 Pg. 263-4 (Mar 1978) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Temperatura tela i reaktsiia na pirogenal u bezmikrobnykh i obychnykh zhivotnykh.
• PMID: 667317 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Pyrogens

Topics

• Animals
• Asepsis
• Body Temperature (drug effects)
• Fever (chemically induced, physiopathology)
• Germ-Free Life
• Immunity, Innate
• Mice
• Pyrogens
• Swine