Polyamine biosynthesis is required for survival of sympathetic neurons after axonal injury.

Abstract

Treatment of adult rats with specific inhibitors of polyamine synthesizing enzymes prevented the early increase in ornithine decarboxylase activity and polyamine content in the superior cervical ganglion after the postganglionic nerve was cut. Moreover, after axotomy, this treatment led to a marked diminution of the chromatolytic response with a marked neuronal cell death. We conclude that after axonal injury an early increase in polyamine biosynthesis, probably within parent sympathetic neurons, is an obligatory step in the progression of the axon reaction.

• Authors: G M Gilad, V H Gilad
• Journal: Brain research (Brain Res) Vol. 273 Issue 1 Pg. 191-4 (Aug 22 1983) ISSN: 0006-8993 [Print] Netherlands
• PMID: 6616228 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polyamines
• Creatine Kinase
• Ornithine Decarboxylase

Topics

• Animals
• Cell Survival
• Creatine Kinase (metabolism)
• Female
• Ganglia, Sympathetic (enzymology, metabolism)
• Ornithine Decarboxylase (metabolism)
• Polyamines (biosynthesis)
• Rats
• Rats, Inbred Strains
• Sympathetic Nervous System (injuries)