[Potentiation by blastolysin of the effect of cyclophosphamide in preventing recurrence in mouse T-cell leukemia].

Abstract

Injection of cyclophosphamide in a dose of 100 mg/kg two or four times at 18- or 7-day intervals, respectively, prolonged the remission in EL-4-leukemia-bearing C57Bl/6j mice induced by cytosar under deoxycytidine protection. Injection of blastolysin in a dose of 25 mg/kg once a week at the same period had no effect. However, blastolysin potentiated the antirelapse effect of cyclophosphamide. It is suggested that the potentiation of the cyclophosphamide effect with blastolysin is mediated by activation of antitumor immunological reactivity.

• Authors: A I Chertkova, V M Bukhman, A B Syrkin
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 98 Issue 7 Pg. 57-9 (Jul 1984) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Potentsirovanie blastolizinom protivoretsidivnogo éffekta tsiklofosfamida pri T-kletochnom leĭkoze mysheĭ.
• PMID: 6466832 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antibiotics, Antineoplastic
• Glycopeptides
• blastolysin
• Cyclophosphamide

Topics

• Animals
• Anti-Bacterial Agents
• Antibiotics, Antineoplastic (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Drug Synergism
• Glycopeptides (therapeutic use)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Recurrence, Local (prevention & control)
• Neoplasm Transplantation
• Thymoma (drug therapy)
• Thymus Neoplasms (drug therapy)