Multiple strains of Plasmodium falciparum are necessary for the growth inhibition assay.

Abstract

Sixty-seven serum samples from individuals living in a malaria endemic area and sixty sera from healthy blood donors living in Bangkok (non-malarious area) were tested for growth inhibition activity against 3 strains (SO, SN and G-112) of Plasmodium falciparum. Forty-eight percent of the sera from the endemic area were positive when all 3 strains were tested. Among the positive sera, positive rates of 90.6% were observed for the SO and SN strain combination, 87.5% for the SO and G-112 combination, and 50% for the SN and G-112 combination. It is therefore recommended that multiple parasite strains should be tested in the growth inhibition assay. If facilities are limited, a minimum of two strains should be used, one of which is the SO strain or its equivalent.

• Authors: J Patarapotikul, S Tharavanij, C Poonthong
• Journal: The Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 14 Issue 2 Pg. 149-53 (Jun 1983) ISSN: 0125-1562 [Print] Thailand
• PMID: 6356378 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies

Topics

• Animals
• Antibodies (analysis)
• Humans
• Immunologic Techniques
• Malaria (immunology)
• Plasmodium falciparum (classification, growth & development, immunology)
• Species Specificity