Pivmecillinam in complicated urinary infections failing to respond to conventional therapy.

Abstract

Forty-three patients with a history of recurrent urinary infections, many of whom had renal involvement and had recently failed treatment, were then treated with pivmecillinam (400 mg 8-hourly for seven days). One week after the end of treatment the bacteriological cure rate was 72.1%. During the following four weeks, however, several of the cured patients relapsed, so that the cure rate five weeks after the end of treatment was only 46%. Thus, it is recommended that such patients should begin prophylactic treatment if found to be abacteriuric after the one week follow-up. Pivmecillinam was extremely well tolerated.

• Authors: W Brumfitt, J M Hamilton-Miller
• Journal: Infection (Infection) Vol. 10 Issue 3 Pg. 149-52 ( 1982) ISSN: 0300-8126 [Print] Germany
• PMID: 6286501 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Drug Combinations
• Amdinocillin Pivoxil
• Penicillanic Acid

Topics

• Adult
• Amdinocillin Pivoxil (therapeutic use)
• Bacterial Infections (drug therapy)
• Bacteriuria (drug therapy)
• Clinical Trials as Topic
• Drug Combinations
• Escherichia coli Infections (drug therapy)
• Female
• Humans
• Klebsiella Infections (drug therapy)
• Klebsiella pneumoniae
• Male
• Middle Aged
• Penicillanic Acid (therapeutic use)
• Proteus Infections (drug therapy)
• Proteus mirabilis
• Recurrence
• Staphylococcal Infections (drug therapy)
• Streptococcal Infections (drug therapy)
• Streptococcus agalactiae
• Urinary Tract Infections (drug therapy)