Correlation between the presence of natural antitumor antibodies and activation of MuLV endogenous virus in BALB/c mice.
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| Abstract |
Individual 3-month-old or 12-month-old BALB/c mice, as well as 5-month-old nu/nu or nu/ + BALB/c mice, showed a direct correlation between the serum level of natural antitumor cytotoxic antibodies and the capacity of spleen cells to infect SC-1 cells permissive for murine ecotropic viruses. Pooled or individual sera from 3-month-old BALB/c mice, negative for the presence of natural antitumor cytotoxic antibodies and whose spleen cells were unable to infect the SC-1 cells, were negative both for SC-1 cells and SC-1 cells infected by MuLV. On the contrary, pooled or individual sera from 15-month-old BALB/c mice, positive for the presence of natural antitumor antibodies and with infecting spleen cells, were cytotoxic for infected SC-1 cells but not for the uninfected ones. The infection of SC-1 cells by MuLV could be inhibited by 3-month-old spleen cells, and this effect was suppressed by depriving the inhibiting spleen cells of T cells by means of an anti-Thy-1 antibody plus complement. The cells with infectious capacity did not belong to the T-cell compartment, as demonstrated by the lack of infection after passing the infecting spleen cells through an anti-Ig column, whereas T-deprivation did not modify the infectious capacity. A natural anti-gp70 monoclonal antibody, which exerted a complement-dependent cytotoxic effect on tumor cells, strongly inhibited the infection of the permissive SC-1 cells by MuLV.
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| Authors | S Ménard, M I Colnaghi, E Tagliabue |
| Journal | Tumori (Tumori) Vol. 67 Issue 4 Pg. 283-92 (Aug 1981) ISSN: 0300-8916 [Print] United States |
| PMID | 6274069 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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