Persistent paramyxovirus infections and behaviour of beta-adrenergic receptors in C-6 rat glioma cells.

Abstract

This paper describes the influence of persistent infections of C-6 rat glioma cells by paramyxoviruses [virus of subacute sclerosing panencephalitis (SSPE) and canine distemper (CDV)] on the cellular beta-adrenergic membrane receptors. The number and binding properties of the beta-adrenergic receptors of the paramyxovirus-infected cells were measured by 3H-dihydroalprenolol binding studies and compared with those of the uninfected C-6 cells. In the case of SSPE virus neither changes in number nor binding properties of beta-adrenergic receptors could be observed, whereas in the case of CDV persistence the number of beta-adrenergic receptors was reduced to about 50%, without an apparent influence on the binding constant for the ligand to the receptors.

• Authors: K Koschel, P Muenzel
• Journal: The Journal of general virology (J Gen Virol) Vol. 47 Issue 2 Pg. 513-7 (Apr 1980) ISSN: 0022-1317 [Print] England
• PMID: 6245183 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Receptors, Adrenergic
• Receptors, Adrenergic, beta
• Dihydroalprenolol

Topics

• Animals
• Cell Line
• Dihydroalprenolol (metabolism)
• Distemper Virus, Canine (physiology)
• Glioma
• Rats
• Receptors, Adrenergic (metabolism)
• Receptors, Adrenergic, beta (analysis, metabolism)
• SSPE Virus (physiology)