Abstract |
The ganglion blocking site of gardneramine (GA) and hirsutine (HS) was studied in the dog urinary bladder in an in situ preparation. GA and HS selectively inhibited the DMPP-induced contraction without having an antagonistic effect on the McN-A-343-induced and acetylcholine-induced contraction. In addition, since GA and HS showed a local anesthetic action weaker than that of procaine, the effect of procaine was studied on the same preparation. Procaine inhibited the McN-A-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction. From these findings, it is concluded that GA and HS inhibited the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.
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Authors | Y Ozaki, M Harada |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 33
Issue 2
Pg. 463-71
(Apr 1983)
ISSN: 0021-5198 [Print] Japan |
PMID | 6193306
(Publication Type: Journal Article)
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Chemical References |
- Alkaloids
- Ganglionic Blockers
- gardneramine
- Procaine
- Dimethylphenylpiperazinium Iodide
- (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride
- Atropine
- Acetylcholine
- hirsutine
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Topics |
- (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride
(pharmacology)
- Acetylcholine
(pharmacology)
- Alkaloids
(pharmacology)
- Animals
- Atropine
(pharmacology)
- Dimethylphenylpiperazinium Iodide
(pharmacology)
- Dogs
- Female
- Ganglionic Blockers
(pharmacology)
- Muscle Contraction
(drug effects)
- Procaine
(pharmacology)
- Urinary Bladder
(physiology)
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