Immunohistochemical localization of S-100 protein and peripheral nerve myelin proteins (P2 protein, P0 protein) in granular cell tumors.

The presence and distribution of nervous-system-specific protein (S-100 protein), peripheral nerve myelin proteins (P2 protein and P0 protein) that have not been given any attention in the field of tumor pathology, and striated muscle-related proteins (myoglobin and myosin) were studied in 18 cases of granular cell tumor by the peroxidase-antiperoxidase method. The granular cells of all cases were negatively stained with anti-striated-muscle-related protein antiserums. On the other hand, they were positively stained with anti-S-100 protein, P2 protein, and P0 protein antiserums. The distribution of P2 protein and P0 protein corresponded with that of characteristic PAS-positive granules on serial sections. Angular bodies in the interstitial cells were also positively stained with anti-P2 protein antiserum and anti-P0 protein antiserum. These results further support the hypothesis that the granular cell tumor is derived from Schwann cells and also suggest that myelin proteins are major core proteins of the characteristic granules and angular bodies of interstitial cells. The biologic significance of these results in relation to myelinogenesis is also discussed.
AuthorsM Mukai
JournalThe American journal of pathology (Am J Pathol) Vol. 112 Issue 2 Pg. 139-46 (Aug 1983) ISSN: 0002-9440 [Print] UNITED STATES
PMID6192721 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Myelin Basic Protein
  • Myelin P0 Protein
  • Myelin P2 Protein
  • Myelin Proteins
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • S100 Proteins
  • Adult
  • Aged
  • Child
  • Cytoplasmic Granules (analysis, ultrastructure)
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Myelin Basic Protein (analysis)
  • Myelin P0 Protein
  • Myelin P2 Protein
  • Myelin Proteins (analysis)
  • Neoplasm Proteins (analysis)
  • Neoplasms, Muscle Tissue (analysis, pathology)
  • Nerve Tissue Proteins (analysis)
  • Neurilemmoma (analysis)
  • Neurofibroma (analysis)
  • Periodic Acid-Schiff Reaction
  • S100 Proteins (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: