[The effect of tetraethylammonium and the decrease in the extracellular chloride concentration on membrane depolarization and contraction of skeletal muscle fiber induced by a hyperpotassium solution].

Abstract

1.--The tetraethylammonium (TEA) effects on K+ contracture and membrane depolarization are compared in both crab and frog skeletal muscle fibres. 2.--The mechanical tension of the contracture is reduced by the TEA in frog skeletal muscle fibre; it is increased in crab skeletal fibre. 3.--When no mechanical phenomenon is observed in frog skeletal muscle, the amplitude and the velocity of membrane depolarization induced by an increase of outward K+ concentration is reduced by the TEA. These effects are in opposition in crab muscle fibre. 4.--In crab muscle fibre, the results obtained tend to show that the C1-ions are not distributed on each side of the membrane according to Donnan equilibrium.

• Authors: G Brûlé, G Haudecoeur
• Journal: Archives internationales de physiologie et de biochimie (Arch Int Physiol Biochim) Vol. 90 Issue 3 Pg. 145-58 (Oct 1982) ISSN: 0003-9799 [Print] Belgium
• Vernacular Title: Influence du tétraéthylammonium et de la diminution de la concentration extracellulaire en chlore sur la dépolarisation membranaire et la contracture de la fibre squelettique induites par un milieu hyperpotassique.
• PMID: 6186212 (Publication Type: English Abstract, Journal Article)

Chemical References

• Chlorides
• Tetraethylammonium Compounds
• Potassium

Topics

• Animals
• Anura
• Brachyura
• Cell Membrane (drug effects)
• Chlorides (pharmacology)
• Muscle Contraction (drug effects)
• Potassium (pharmacology)
• Tetraethylammonium Compounds (pharmacology)