The effect of the glutamine analog, AT-125, on the cell cycle of MCF-7 and BT-20 human breast carcinoma cells using DNA flow cytometry.

Abstract

It was found by DNA flow cytometry that AT-125 preferentially inhibited the cell cycle progression in G1-phase of BT-20 more so than MCF-7 breast carcinoma cells in vitro and that cells washed free of the drug now possessed S-phase DNA content. It was also found that gamma-glutamyl transpeptidase levels were more than 2 times higher in BT-20 than in MCF-7 cells.

• Authors: J T Thornthwaite, L M Allen
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 29 Issue 2 Pg. 393-6 (Aug 1980) ISSN: 0034-5164 [Print] United States
• PMID: 6106266 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Isoxazoles
• Oxazoles
• gamma-Glutamyltransferase
• acivicin
• Glycine

Topics

• Antineoplastic Agents (pharmacology)
• Breast Neoplasms (enzymology, pathology)
• Cell Cycle (drug effects)
• Cell Line
• Cytological Techniques
• DNA, Neoplasm (biosynthesis)
• Glycine (analogs & derivatives, pharmacology)
• Humans
• Isoxazoles (pharmacology)
• Oxazoles (pharmacology)
• gamma-Glutamyltransferase (metabolism)