Abstract |
Hypoxia (95% N2; 5% CO2) led to complete or partial inhibition of spontaneous contractile activity of isolated segment of the rat thoracic lymphatic duct, PO2 of perfused solution being 5--10 mm Hg. Reoxygenation restored rhythmical although more frequent contractions of the smooth muscle cells. Excitability of cells membrane tested with KCl, BaCl2, and noradrenaline during hypoxic period proved lower during this decreased PO2. Preliminary depolarization with KCl, BaCl2, and noradrenaline of cells membrane delayed the inhibition of contractile activity during hypoxia. Compared with the portal vein, lymphatic duct revealed a greater resistance to hypoxia. The hypoxia seems to affect first the smooth muscle cell membrane which leads to modification of the contraction character.
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Authors | N A Gladysheva |
Journal | Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova
(Fiziol Zh SSSR Im I M Sechenova)
Vol. 65
Issue 10
Pg. 1520-6
(Oct 1979)
ISSN: 0015-329X [Print] Russia (Federation) |
Vernacular Title | Vliianie gipoksii na sokratitel'nuiu aktivnost' gladkomyshechnykh kletok grudnogo limfaticheskogo protoka. |
PMID | 510603
(Publication Type: Journal Article)
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Chemical References |
- Phosphocreatine
- Adenosine Triphosphate
- Sodium
- Calcium
- Norepinephrine
|
Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Calcium
(metabolism)
- Cell Membrane Permeability
- Female
- Hypoxia
(physiopathology)
- Male
- Muscle Contraction
- Muscle, Smooth
(metabolism, physiopathology)
- Norepinephrine
- Periodicity
- Phosphocreatine
(metabolism)
- Rats
- Sodium
(metabolism)
- Thoracic Duct
(metabolism, physiopathology)
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