Tumor initiating activity of 5,11-dimethylchrysene and the structural requirements favoring carcinogenicity of methylated polynuclear aromatic hydrocarbons.

Abstract

The tumor initiating activities of 5,11-dimethylchrysene and 5-methylchrysene on mouse skin were compared. After initiating doses of 30 microgram or 10 microgram, with promotion by 3 times weekly applications of tetradecanoylphorbol acetate, both compounds were highly tumorigenic, inducing tumors in 70--85% of the treated animals. Since 5,12-dimethylchrysene had previously been shown to be only a weak tumor initiator, these results support the generalization that the structural requirements favoring carcinogenicity among the methylated chrysenes and other polynuclear aromatic hydrocarbons (PAH) are a bay region methyl group and a free peri position, both adjacent to an unsubstituted angular ring.

• Authors: S S Hecht, S Amin, A Rivenson, D Hoffmann
• Journal: Cancer letters (Cancer Lett) Vol. 8 Issue 1 Pg. 65-70 (Nov 1979) ISSN: 0304-3835 [Print] Ireland
• PMID: 509421 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Chrysenes
• Phenanthrenes
• Polycyclic Compounds

Topics

• Animals
• Chrysenes (toxicity)
• Female
• Methylation
• Mice
• Neoplasms, Experimental (chemically induced)
• Phenanthrenes (toxicity)
• Polycyclic Compounds (toxicity)
• Skin Neoplasms (chemically induced)
• Structure-Activity Relationship