Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma.

Abstract

Quantitative differences in the tyrosinase activity are found at the three types of malignant melanoma of Clark and Mihm by the combined 3,4-dihydroxyphenylalanine-premelanin-reaction. Only a very small activity is present in the junction nevus. In the superficial spreading melanoma the tyrosinase activity is clear, but limited. The lentigo maligna melanoma shows an increased pigmentation. The topmost activity after incubation however is present in the nodular melanoma.

• Authors: R Haensch
• Journal: Archiv fur dermatologische Forschung (Arch Dermatol Forsch) Vol. 252 Issue 3 Pg. 193-201 ( 1975) ISSN: 0003-9187 [Print] Germany
• PMID: 50762 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Melanins
• Catechol Oxidase

Topics

• Catechol Oxidase (metabolism)
• Diagnosis, Differential
• Humans
• Melanins (analysis)
• Melanoma (classification, enzymology)
• Nevus (enzymology)
• Skin Neoplasms (enzymology)
• Staining and Labeling