Volatile N-nitrosamines in the urine of normal donors and of bladder cancer patients.

Abstract

Volatile N-nitrosamines were detected in the urine of male volunteers with gas-liquid and high-pressure liquid chromatography interfaced to the thermal energy analyzer. Of 50 samples from normal males, 10 contained nitrosodimethylamine (0.02 to 0.10 micrograms/liter), 6 contained nitrosodiethylamine (0.02 to 3.10), 9 contained nitrosomorpholine (0.006 to 0.67), and none contained nitrosodibutylamine. Of 4 samples from bladder cancer patients, 2 contained nitrosodibutylamine (0.35 and 0.66). Cigarette smoking did not appear to be related to the pattern or amount of urinary volatile N-nitrosamines. The possibility that the N-nitrosamines arise from the diet or from endogenous production is considered.

• Authors: T Kakizoe, T T Wang, V W Eng, R Furrer, P Dion, W R Bruce
• Journal: Cancer research (Cancer Res) Vol. 39 Issue 3 Pg. 829-32 (Mar 1979) ISSN: 0008-5472 [Print] United States
• PMID: 427771 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Nitrosamines
• Diethylnitrosamine
• Dimethylnitrosamine

Topics

• Adult
• Aged
• Chromatography, High Pressure Liquid
• Diethylnitrosamine (metabolism)
• Dimethylnitrosamine (metabolism)
• Humans
• Male
• Middle Aged
• Nitrosamines (analysis, metabolism)
• Smoking (physiopathology)
• Urinary Bladder Neoplasms (urine)