HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Biochemical and behavioural effects of hypoxic hypoxia in rats: study of the protection afforded by ergot alkaloids.

Abstract
The conditioned avoidance response and the cerebral levels of dopamine and noradrenaline have been studied in control rats and in rats submitted to a hypobaric hypoxia. A protection against the effects of hypoxia was induced by both dihydroergocornine (20 microgram/kg) and dihydroergocryptine (100 microgram/kg), and the noradrenaline level did not decrease. This stabilization of cerebral noradrenaline level seems to be the main protection factor observed.
AuthorsF Boismare, M Le Poncin, J Lefrançois
JournalGerontology (Gerontology) Vol. 24 Suppl 1 Pg. 6-13 ( 1978) ISSN: 0304-324X [Print] Switzerland
PMID412730 (Publication Type: Journal Article)
Chemical References
  • Catecholamines
  • Dihydroergotoxine
  • Ergoloid Mesylates
  • Dopamine
  • Norepinephrine
Topics
  • Animals
  • Avoidance Learning (drug effects)
  • Brain (metabolism)
  • Catecholamines (metabolism)
  • Dihydroergotoxine (pharmacology)
  • Dopamine (metabolism)
  • Dose-Response Relationship, Drug
  • Ergoloid Mesylates (pharmacology)
  • Female
  • Hypoxia, Brain (metabolism, prevention & control)
  • Norepinephrine (metabolism)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: