Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine and norepinephrine release from cortical slices of bilaterally carotid-artery-ligated Mongolian gerbils.

Abstract	Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine (ACh) and norepinephrine (NE) release from cortical slices of bilaterally carotid-artery-ligated Mongolian gerbils were examined. ACh and NE release from cortical slices of Mongolian gerbils were increased 1 hr after the ligation of bilateral carotid arteries. Pretreatment of MCI-2016 (25 mg/kg, i.p.) attenuated the increase in the release of both neurotransmitters. These effects may participate in the protective effect of MCI-2016 on cerebral ischemia in Mongolian gerbils.
Authors	K Saito, S Honda, M Egawa, A Tobe
Journal	Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 39 Issue 3 Pg. 406-9 (Nov 1985) ISSN: 0021-5198 [Print] Japan
PMID	4094185 (Publication Type: Journal Article)
Chemical References	Antidepressive Agents Benzhydryl Compounds Acetylcholine Norepinephrine bifemelane
Topics	Acetylcholine (metabolism) Animals Antidepressive Agents (pharmacology) Benzhydryl Compounds (pharmacology) Carotid Arteries (physiology) Cerebral Cortex (metabolism) Gerbillinae Ligation Male Norepinephrine (metabolism) Time Factors

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