[Effectiveness of D-penicillamine therapy in chronic polyarthritis].

Abstract

In 52 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for two years in a prospective trial. Patients were included in the study only if the duration of their disease exceeded 6 months (upper limit 12 months), and there was involvement of 6 or more joints and an elevated erythrocyte sedimentation rate (1 hour values greater than or equal to 25 mm). In 26 patients (50%) a decline in the activity index could be observed, but 18 of these subjects had a deterioration of findings as assessed by X-ray. The increase of the activity index indicated no therapeutic benefit in 26 patients (50%), which could be confirmed in 23 subjects by X-rays.

• Authors: H Rautenstrauch, W Laschner, J G Saal
• Journal: Zeitschrift fur Rheumatologie (Z Rheumatol) 1985 Jul-Aug Vol. 44 Issue 4 Pg. 192-7 ISSN: 0340-1855 [Print] Germany
• Vernacular Title: Untersuchungen über die Wirksamkeit der D-Penicillamintherapie bei chronischer Polyarthritis.
• PMID: 4050151 (Publication Type: Journal Article)

Chemical References

• Penicillamine

Topics

• Adult
• Aged
• Arthritis, Rheumatoid (diagnostic imaging, drug therapy)
• Arthrography
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Penicillamine (therapeutic use)