Abstract |
The efficacy of orally administered mycophenolic acid (MPA), an inhibitor of guanosine monophosphate (GMP) synthesis, for the treatment of psoriasis, was studied in a double-blind fashion. Of twenty-one patients completing the study period, ten of eleven patients treated with MPA had a greater than 25% decrease in severity score compared with only two of ten patients treated with placebo. The placebo group had a slight increase in severity score compared to almost 50% reduction in the average severity score of the MPA-treated group. After termination of the double-blind portion of the study, the placebo group was treated with MPA and showed a 60% decrease in severity score. Adverse effects encountered included anorexia, nausea, vomiting, and diarrhea. One patient had an uncomplicated episode of herpes zoster. Other than a mild decrease hemoglobin, no hematologic toxicity was noted.
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Authors | E C Gomez, L Menendez, P Frost |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 1
Issue 6
Pg. 531-7
(Dec 1979)
ISSN: 0190-9622 [Print] United States |
PMID | 393732
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Placebos
- Mycophenolic Acid
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Topics |
- Adult
- Aged
- Clinical Trials as Topic
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Gastrointestinal Diseases
(chemically induced)
- Humans
- Male
- Middle Aged
- Mycophenolic Acid
(administration & dosage, adverse effects, therapeutic use)
- Placebos
- Psoriasis
(drug therapy)
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