Ankylosing spondylitis is a systemic rheumatic disorder that is characterized by
inflammation of the spine, sacroiliac, and large peripheral joints. Although
back pain is the most frequent presenting symptom, disease can begin in peripheral joints--especially in children and women--and, rarely, even with acute
iritis. Whatever the mode of onset, recurrent
back pain that is frequently nocturnal and of varying intensity is an eventual complaint, as is early morning stiffness that is typically relieved by activity. The long-term prognosis is clearly enhanced by early diagnosis and patient education, both of which are central to preventing or minimizing disability. By suppressing articular
inflammation,
pain, and stiffness, the nonsteroidal anti-inflammatory drugs facilitate exercise and other supportive measures. Currently, among these agents,
indomethacin occupies an important place. By virtue of its 12-hour dosage system, sustained-release
indomethacin can be prescribed only once or twice daily, providing the anti-inflammatory efficacy of
indomethacin while promoting patient compliance.