Clinical study of co-trimazine in urinary tract infections: a comparison with nitrofurantoin.

Abstract

Co-trimazine, a new preparation of sulphadiazine and trimethoprim, was compared with nitrofurantoin in a double-blind trial on patients with acute urinary tract infections. Co-trimazine had a bacteriological cure rate of 95% as compared to 88% for nitrofurantoin. There were no statistically significant differences in laboratory findings or in clinical side-effects between the two laboratory findings or in clinical side-effects between the two preparations. It was concluded that co-trimazine might constitute a valuable addition amongst drugs suitable for treatment of acute urinary tract infections.

• Authors: J Belsheim, H Gnarpe, A Helleberg, A Svensson
• Journal: Infection (Infection) Vol. 7 Suppl 4 Pg. S411-3 ( 1979) ISSN: 0300-8126 [Print] Germany
• PMID: 389817 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Sulfadiazine
• Nitrofurantoin
• Trimethoprim

Topics

• Adolescent
• Adult
• Clinical Trials as Topic
• Double-Blind Method
• Drug Combinations
• Female
• Humans
• Male
• Middle Aged
• Nitrofurantoin (adverse effects, therapeutic use)
• Sulfadiazine (adverse effects, therapeutic use)
• Trimethoprim (adverse effects, therapeutic use)
• Urinary Tract Infections (drug therapy, microbiology)