[Effect of litonit and teturam on the course of biochemical processes in infectious inflammatory lesions of the kidneys in alcoholized animals].

Abstract

The time-course of changes in the activity of sorbitol dehydrogenase, catalase and the intensity of lipid peroxidation in the blood and kidneys of 250 albino rats was studied in the course of the development of alcoholic dependence when suffering from secondary infection. Litonit, a new antialcoholic drug, was found to be effective for the treatment of infectious inflammatory renal lesions in alcoholism. Unlike teturam, litonit promoted the decrease of sorbitol dehydrogenase and catalase activity in the kidneys and abated the intensity of lipid peroxidation. The possibility of using litonit as one of the remedies of pathogenetic therapy for infectious inflammatory renal lesions in alcoholism is under discussion.

• Authors: F I Kostev
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 99 Issue 6 Pg. 661-3 (Jun 1985) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie litonita i teturama na techenie nekotorykh biokhimicheskikh protsessov pri infektsionno-vospalitel'nykh proazheniiakh pochek u alkogolizirovannykh zhivotnykh.
• PMID: 3893564 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Lipid Peroxides
• Nicotinic Acids
• Tranquilizing Agents
• litonit
• L-Iditol 2-Dehydrogenase
• Catalase
• Disulfiram

Topics

• Alcoholism (complications, drug therapy, metabolism)
• Animals
• Catalase (metabolism)
• Disulfiram (therapeutic use)
• Drug Evaluation, Preclinical
• Escherichia coli Infections (drug therapy, metabolism)
• Humans
• Kidney (drug effects, metabolism)
• Kidney Diseases (drug therapy, metabolism)
• L-Iditol 2-Dehydrogenase (metabolism)
• Lipid Peroxides (metabolism)
• Nicotinic Acids (therapeutic use)
• Rats
• Tranquilizing Agents (therapeutic use)