The pharmacokinetics of cimetidine and metabolites in a neonate.

Abstract

Limited pharmacokinetic data have been reported concerning the use of cimetidine in the neonate for the management of gastrointestinal hemorrhage. After receiving cimetidine at a dose of 10 mg/kg/d in a full-term infant, the steady-state peak and four-hour concentrations were 3.5 and 1.8 micrograms/ml, respectively. A mean half-life of 3.6 h for cimetidine and 2.2 h for cimetidine sulfoxide were determined. The cimetidine half-life was prolonged, and the total body clearance decreased as compared with values reported in critically ill children and adults.

• Authors: C W Lloyd, W J Martin, B D Taylor
• Journal: Drug intelligence & clinical pharmacy (Drug Intell Clin Pharm) Vol. 19 Issue 3 Pg. 203-5 (Mar 1985) ISSN: 0012-6578 [Print] United States
• PMID: 3884305 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cimetidine

Topics

• Biotransformation
• Cimetidine (metabolism, therapeutic use)
• Gastrointestinal Hemorrhage (complications, drug therapy, metabolism)
• Half-Life
• Humans
• Infant, Newborn
• Kinetics
• Male
• Streptococcal Infections (complications)
• Streptococcus agalactiae