Pulsatile subcutaneous nocturnal administration of GnRH by portable infusion pump in hypogonadotropic hypogonadism: initiation of gonadotropin responsiveness.

Abstract

GnRH was administered subcutaneously in hourly pulses for 10 consecutive nights to two immature males with Kallmann's Syndrome using a portable, battery-operated infusion pump adapted for home use. Pulsatile GnRH produced a progressive increase in urinary gonadotropin excretion, a significant increase in mean basal plasma FSH, pulsatile LH release, and an increased LH response to a standard 3 hour GnRH infusion test. One subject developed a striking increment in plasma testosterone in response to GnRH pulses, as well as a biphasic LH response to the 3 hour infusion.

• Authors: R I Jacobson, L E Seyler Jr, W V Tamborlane Jr, J M Gertner, M Genel
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 49 Issue 4 Pg. 652-4 (Oct 1979) ISSN: 0021-972X [Print] United States
• PMID: 383741 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Gonadotropin-Releasing Hormone
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Adolescent
• Follicle Stimulating Hormone (blood)
• Gonadotropin-Releasing Hormone
• Humans
• Hypogonadism (blood)
• Kinetics
• Luteinizing Hormone (blood)
• Male